TABLE 4.

Kinetic analysis of HIV-1 protease with individual mutations^a

Mutation	Ratio of Ki of the mutant to Ki of the wild type for:
	APV	SQV
M46I	0.5	1
G48V	4b	160b
I50V	83	21
I84L	0.2	4
Quadruple	2	300

^aFor details of the conditions used, see the footnotes to Tables 2 and 3. 

^bData from reference 7.