Figure 6.

DSRCT shows interpatient heterogeneity and scRNA-seq-derived gene signatures define DSRCT patients’ prognostic groups

(A) DSRCT bulk RNA-seq Int_sc clusters deconvolution.

(B) DSRCT bulk RNA-seq samples hierarchical clustering highlighting three distinct subgroups.

(C) Kaplan-Meier overall survival plot according to DSRCT bulk RNA-seq hierarchical clustering subgroups. p values are calculated using the log rank test.

(D and E) Specificity and prognostic significance of the Cycling cells – 3 (D) and epithelial-mesenchymal) – 4 (E) signature scores. The signature specificity is assessed by comparing its value in a DSRCT bulk RNA-seq dataset versus other sarcoma subtypes. The Kaplan-Meier plot shows the overall survival according to High or Low 3′ scRNA-seq derived signatures’ scores. P values are calculated using the log rank test.