REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-human CD2	BD Biosciences	Cat#: 555326; RRID: AB_395733
Anti-human CD3	BD Biosciences	Cat#: 349201; RRID: AB_400405
Anti-human CD4	ThermoFisher	Cat#: MHCD0401; RRID:AB_10392546
Anti-human CD7	BioLegend	Cat#: 343104; RRID: AB_1659216
Anti-human CD11b	ThermoFisher	Cat#: 11-0118-42; RRID: AB_1582242
anti-human CD14	BD Biosciences	Cat#: 347493; RRID: AB_400311
Anti-human CD19	BD Biosciences	Cat#: 340409; RRID: AB_400024
Anti-human CD20	BD Biosciences	Cat#: 555622; RRID: AB_395988
Anti-human CD33	ThermoFisher	Cat#: 11-0337-42; RRID: AB_1603221
Anti-human CD56	BD Biosciences	Cat#: 562794; RRID: AB_2737799
Anti-human CD235	BD Biosciences	Cat#: 559943; RRID: AB_397386
Anti-human CD34	BD Biosciences	Cat#: 562577; RRID: AB_2687922
Anti-human CD38	BioLegend	Cat#: 303534; RRID: AB_2561605
Anti-human CD3	BioLegend	Cat#: 317339; RRID: AB_2563407
Anti-human CD4	BioLegend	Cat#: 300502; RRID: AB_314070
Anti-human CD8	BioLegend	Cat#: 344710; RRID: AB_2044010
Anti-human CD56	BioLegend	Cat#: 362544; RRID: AB_2565922
Anti-human CD16	BioLegend	Cat#: 302028; RRID: AB_893262
Anti-Human IFN-γ	BD Biosciences	Cat#: 554702; RRID: AB_398580
Anti-human Perforin	BioLegend	Cat#: 308130; RRID: AB_2687190
Zombie UV	BioLegend	Cat#: 423107
Protein Transport Inhibitor Cocktail	eBioscience	Cat#: 00-4980-93
Fc Receptor Binding Inhibitor Polyclonal Antibody	ThermoFisher	Cat#: 14-9161-73
CD3e	Cell Signaling Technology	Cat#: 85061BF; RRID: AB_2721019
CD4	Abcam	Cat#: ab133616; RRID: AB_2750883
CD8	Thermo Scientific	Catalog#: MA5-13473; RRID: AB_11000353
CD14	Abcam	Cat#: ab183322; RRID: AB_2909463
CD68, Clone PG-M1	Dako	Cat#: M0876; RRID: AB_2074844
CD56	Dako	Cat#: M7304; RRID: AB_2750583
DAPI	Akoya Biosciences	Cat#: FP1490; RRID: N/A
MCL1	Cell Signaling Technology	Cat#: 4572; RRID:AB_2281980
Vinculin	Sigma-Aldrich	Cat#: V9131; RRID:AB_477629
Biological samples
Bone marrow aspirates from healthy donors	AllCells (Alameda, CA) and MD Anderson’s Department of Stem Cell Transplantation	N/A
Bone marrow aspirates from CMML patients	MD Anderson Bank	N/A
Human bone marrow-derived mesenchymal stem cells	Cells provided by Dr. M. Andreeff	N/A
Chemicals, peptides, and recombinant proteins
AMG-176	Med Chem Express	Cat#: HY-101565
Critical commercial assays
Cytofix/Cytoperm kit	BD Biosciences	Cat#: 554714
Deposited data
scRNA-seq data	This paper	GEO: GSE218390
scATAC-seq data	This paper	GEO: GSE218390
scDNA-seq data	This paper	GEO: GSE218390
Experimental models: Cell lines
K562 cells	ATCC	ATCC CCL243
Software and algorithms
SPSS 23.0	SPSS, Inc	https://www.ibm.com/products/spss-statistics
R v4.1.2	R Core Team	https://www.r-project.org
Seurat v4 R package ‘	Hao et al.50	https://github.com/satijalab/seurat
CellphoneDB	Vento-Tormo et al.51	https://www.cellphonedb.org/
GraphPad Prism version 10.0	GraphPad software	https://www.graphpad.com/
Spotfire	TIBCO	N/A
FlowJo	BD Biosciences	https://www.flowjo.com/
GSEA	Metascape	https://metascape.org/
Spotfire	TIBCO	https://www.spotfire.com/
Other
Ficoll-Paque PLUS	ThermoFisher	Cat#:45-001-752
CD34 Microbead Kit	Miltenyi Biotec	Cat#:130-046-702
NK Cell Isolation Kit	Miltenyi Biotec	Cat#: 130-092-657
Opal 9 Kit	Akoya Biosciences	Cat#: NEL797001KT
Qubit	Thermo Fisher Scientific	N/A