Table 1. Description of cohort of patients in the National Cancer Database with non-small cell lung cancer, who either had no metastatic cancer or isolated brain metastasis.
| Characteristics | No metastasis | Isolated brain metastasis | P value |
|---|---|---|---|
| Age (years) | 70 [18–90] | 66 [18–90] | <0.001 |
| Male (versus female) | 179,040 (48.4) | 12,953 (50.0) | <0.001 |
| Caucasian | 306,587 (82.8) | 20,098 (77.6) | <0.001 |
| Insurance status | <0.001 | ||
| Not insured | 4,977 (1.3) | 910 (3.5) | |
| Private insurance | 79,273 (21.4) | 7,285 (28.1) | |
| Medicaid | 23,270 (6.3) | 3,181 (12.3) | |
| Medicare | 250,211 (67.6) | 13,602 (52.5) | |
| Other | 8,842 (2.4) | 599 (2.3) | |
| Unknown | 3,633 (1.0) | 330 (1.3) | |
| Academic program | 195,274 (52.7) | 14,231 (54.9) | <0.001 |
| Histology | <0.001 | ||
| Adenocarcinoma | 190,068 (51.3) | 18,494 (71.4) | |
| Squamous carcinoma | 128,569 (34.7) | 3,796 (14.7) | |
| Other | 51,569 (13.9) | 3,617 (14.0) | |
| Grade | <0.001 | ||
| Well-differentiated | 29,319 (7.9) | 356 (1.4) | |
| Moderately differentiated | 72,926 (19.7) | 2,246 (8.7) | |
| Poorly differentiated | 67,908 (18.3) | 6,443 (24.9) | |
| Undifferentiated | 1,539 (0.4) | 170 (0.7) | |
| Cannot be assessed/unknown | 198,514 (53.6) | 16,692 (64.4) | |
| Clinical T-stage | <0.001 | ||
| cT1 | 113,464 (30.6) | 3,157 (12.2) | |
| cT2 | 54,726 (14.8) | 4,887 (18.9) | |
| cT3 | 27,523 (7.4) | 2,919 (11.3) | |
| cT4 | 22,307 (6.0) | 2,764 (10.7) | |
| Missing | 152,186 (41.1) | 12,180 (47.0) | |
| Clinical N-stage | <0.001 | ||
| cN0 | 157,785 (42.6) | 4,664 (18.0) | |
| cN1 | 15,422 (4.2) | 1,764 (6.8) | |
| cN2 | 39,400 (10.6) | 5,853 (22.6) | |
| cN3 | 12,809 (3.5) | 2,132 (8.2) | |
| Missing | 144,790 (39.1) | 11,494 (44.4) | |
| Charlson/Deyo comorbidity score | <0.001 | ||
| 0 | 203,991(55.1) | 16,632 (64.2) | |
| 1 | 91,024 (24.6) | 5,275 (20.4) | |
| 2 | 40,938 (11.1) | 2,212 (8.5) | |
| ≥3 | 34,253 (9.3) | 1,788 (6.9) |
Data shown includes median and interquartile range for continuous variables or n (%) for categorical variables. Differences calculated using chi-square or rank sum test.