Table 3. Treatment-related adverse events.

Adverse events	Grade 1	Grade 2	Grade 3	Grade 4
Nausea	12 [60]	3 [15]	1 [5]	0
Fatigue	10 [50]	3 [15]	1 [5]	0
Diarrhea	10 [50]	2 [10]	0	0
Vomiting	8 [40]	2 [10]	0	0
Anorexia	7 [35]	4 [20]	1 [5]	0
Dyspepsia	6 [30]	2 [10]	0	0
Oral mucositis	5 [25]	0	0	0
Myalgia	3 [15]	1 [5]	0	0
Hypertension	2 [10]	3 [15]	1 [5]	0
Arthralgia	2 [10]	0	0	0
Dizziness	2 [10]	0	0	0
Edema	2 [10]	0	0	0
Headache	2 [10]	0	0	0
Rash	2 [10]	0	0	0
Sweating	2 [10]	0	0	0
Tremor	2 [10]	0	0	0
Fever	1 [5]	1 [5]	0	0
Alopecia	1 [5]	0	0	0
Constipation	1 [5]	0	0	0
Cough	1 [5]	0	0	0
Dry mouth	1 [5]	0	0	0
Dry skin	1 [5]	0	0	0
Dysgeusia	1 [5]	0	0	0
Dysphagia	1 [5]	0	0	0
Feet cramps	1 [5]	0	0	0
Hot flashes	1 [5]	0	0	0
Hyperpigmentation	1 [5]	0	0	0
Insomnia	1 [5]	0	0	0
Lightheadedness	1 [5]	0	0	0
Non-cardiac chest pain	1 [5]	0	0	0
Bilateral leg pain	1 [5]	0	0	0
Infection	0	3 [15]	0	0
Peptic ulcer disease	0	1 [5]	0	0
Seizure	0	1 [5]	0	0
Weight loss	0	1 [5]	0	0
Alanine aminotransferase increased	0	0	2 [10]	1 [5]
Aspartate aminotransferase increased	0	0	2 [10]	1 [5]
Bilirubin increased	0	0	1 [5]	0
Cerebral edema	0	0	0	1 [5]

Data are presented as n [%].