FIG. 4.

Alignment of the amino acid sequences predicted to be encoded by RCMV r127, GPV NS1, and HHV-6A U94. The alignment was carried out by using a CLUSTAL W Multiple Sequence Alignment Program (45). Numbers to the left of the sequences indicate the positions of amino acid residues within the polypeptides. Blocks of identical (white letters in black boxes) and similar (white letters in grey boxes) residues were generated with program BOXSHADE (version 3.21), with the fraction of sequences that must agree for shading set to 0.5. The sequence motifs depicted with A, B, B', and C represent strongly conserved putative NTP binding helicase regions (21, 26). The sequences encoded by GPV NS1 and HHV-6A U94 were from Zadori et al. (53) and Thomson et al. (46), respectively.