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Example FLAIR images and corresponding masks traced by two human experts and marked in red. The left three are a flair image, 1st rater’s mask, 2nd rater’s mask from subject-01’s first time-point scan. The right three are from subject-02’s first time-point scan. We can see from the figure, besides ms lesion areas, there are many other hyperintensities that can confuse algorithms or even human experts.
