Table 3.

MiRNAs that were significantly upregulated in plasma EVs

MicroRNA	Expression*	Log2FoldChange	Standard Error	Adjusted p-value
miR-141-3p	197.09	7.6890	0.9961	2.22E-12
miR-200a-3p	251.64	7.3058	1.0524	2.44E-10
miR-200b-3p	88.782	7.2339	1.2811	7.77E-07
miR-429	13.077	6.5386	1.1678	8.18E-07
miR-200c-3p	235.39	6.3926	0.9142	2.44E-10
miR-196a-5p	13.382	4.6913	1.0493	0.0002
miR-375-3p	13.756	4.6179	0.9026	0.0000
miR-192-5p	305.94	2.4751	0.5925	0.0006
miR-194-5p	111.04	2.0845	0.5925	0.0059
miR-92b-3p	16.172	1.9158	0.5403	0.0059
miR-21-5p	2359.4	1.8383	0.5021	0.0048
miR-148a-3p	415.54	1.1132	0.3436	0.0151

Shown are significant (adjusted p-values < 0.05) miRNA candidates identified by small RNA sequencing and sorted by descending log fold change values. Expression averaged across all samples with normalization by DESeq2 to allow direct comparison between the samples. Standard errors are of the log2 fold change and p-values are adjusted using the Benjamini-Hochberg method. In bold are candidates used in later validation. *Expressed in reads per million