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. 2024 Jul 8;25:42. doi: 10.1186/s12865-024-00635-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The mRNA level of LCP1 in normal tissues and TNBC. A The LCP1mRNA level in human normal tissues using Genotype Tissue-Expression (GTEX) data. B Comparison of the LCP1 mRNA level in TCGA-TNBC and TCGA normal breast tissues. The red dots represent the cancer samples, and the blue dots represents the normal samples. C, D Comparison of the LCP1 mRNA level in TNBC tissues and normal tissues validated by GSE38959 and GSE65194 datasets. E The mRNA level Expression of LCP1 in BRCA based on breast cancer subclasses(Normal-vs-Luminal P= 3.58529999999746E-05, Normal-vs-TNBC P= 7.85030040972856E-10; Luminal-vs-TNBC P= 2.06219999999702E-05). F LCP1 proteomic expression profile based on Major subclass using data from Clinical Proteomic Tumor Analysis Consortium (CPTAC) and the International Cancer Proteogenome Consortium (ICPC) datasets(Normal-vs-TNBC P=1.705679E-02;Luminal-vs-TNBC P= 3.499659E-03). G The mRNA level of LCP1 in different breast cancer subtypes in TCGA database.*, P < 0.05; **, P < 0.01; and ***, P < 0.001