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. 2024 May 15;52(12):6830–6849. doi: 10.1093/nar/gkae370

Figure 6.

Figure 6.

DepMap data reveal an association between increased A-MYB expression and low impact of B-MYB loss on proliferation and survival. (A) A cell line screen from the DepMap database compares the mRNA expression level of A-MYB and B-MYB in 2900 cell lines in a boxplot. Two additional boxplots based on the DepMap database correlate the mRNA expression of A-MYB (y-axis) with the impact of (B) B-MYB loss by siRNA knockdown (B-MYB RNAi gene effect on the x-axis) in 660 cell lines and (C) B-MYB knockout (B-MYB CRISPR gene effect on the x-axis) in 1003 cell lines on cell proliferation and survival. The impact of B-MYB loss was categorized into low (gene effect > −0.5), medium (gene effect ≤ −0.5 and > −1), or high (gene effect ≤ −1) negative effect on proliferation and survival. For these analyses the effects are considered relative to a set of genes, which cells are fully dependent on. The effects of those genes are set to −1. Significances were calculated by two-way ANOVA (*P < 0.05; **P < 0.01; ***P < 0.001).