Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 May 6;52(12):7225–7244. doi: 10.1093/nar/gkae319

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 8. — PRMT5-dependent FXR1 preferentially targets oncogenes and alters its expression in HNSCC. (A) Kaplan–Meier plots of overall survival of stage HNSCC patients (n = 522) stratified by FXR1 and PRMT5 mRNA expression (SD > 1). The log-rank P value and the number of cases per group are shown. (B) Optimized multiplex immunofluorescence showing the expression of FXR1 and PRMT5 in human HNSCC tumor and normal adjacent tissue samples. DAPI and CD3 staining was done for the nucleus and tumor markers. (C) Model represents the methylation dependent regulation of FXR1 and its RNA targets to promote or inhibit the tumor cell proliferation.