Table 3.

Comparison of IC₅₀ of XYZ-1–71, XYZ-I-73, 5-FU, GemHCl, and Irinotecan.

Compound	MiaPaCa-2		PANC-1		BxPC-3
	IC50 (μM)	p-value	IC50 (μM)	p-value	IC50 (μM)	p-value
	12.3 ± 1.7	12.3 ± 1.7(XYZ-I-71) vs 3.6 ± 0.4 (XYZ-I 73)***	8.7 ± 0.9	8.7 ± 0.9 (XYZ-I-71) vs 3.9 ± 0.5 (XYZ-I-73)*	7.7 ± 0.8	7.7 ± 0.8 (XYZ-I-71) vs $5.9\pm {0.7}_{(\text{XYZ}-1-73)}^{\text{ns}}$
	3.6 ± 0.4	3.6 ± 0.4 (XYZ-I 73) *** vs 12.3 ± 1.7 (XYZ-I-71)	3.9 ± 0.5	3.9 ± 0.5 (XYZ-I-73)* vs 8.7 ± 0.9 (XYZ-I-71)	5.9 ± 0.7	5.9 ± 0.7 (XYZ-I-73) vs $7.7\pm {0.8}_{(\text{XYZ}-\text{I}-71)}^{\text{ns}}$
	13.2 ± 1.1	12.3 ± 1.7(XYZ-I-71) vs $13.2\pm {1.1}_{(5-\text{FU})}^{\text{ns}}$ 3.6 ± 0.4(XYZ-I-73) *** vs 13.2 ± 1.1 (5-FU)	20.4 ± 1.2	8.7 ± 0.9 (XYZ-I-71)*** vs 20.4 ± 1.2 (5-FU) 3.9 ± 0.5 (XYZ-I-73)*** VS 20.4 ± 0.5 (5-FU)	14.0 ± 1.1	7.7 ± 0.8 (XYZ-I-71)*** VS 14.0 ± 1.1 (5-FU) 5.9 ± 0.7 (XYZ-I-73)*** VS 14.0 ± 1.1 (5-FU)
	24.2 ± 1.3	12.3 ± 1.7(XYZ-I-71)*** vs 24.2 ± 1.7 (GemHCl) 3.6 ± 0.4 (XYZ-I 73)*** vs 24.2 ± 1.7 (GemHCl)	10.1 ± 0.9	8.7 ± 0.9 (XYZ-I-71) ns vs 10.1 ± 0.9 (GemHCl) 3.9 ± 0.5 (XYZ-I-73)** VS 10.1 ± 0.9 (GemHCl)	11.0 ± 0.9	7.7 ± 0.8 (XYZ-I-71)* VS 11.0 ± 0.9 (GemHCl) 5.9 ± 0.7 (XYZ-I-73)** VS 11.0 ± 0.9 (GemHCl)
	10.1 ± 1.5	12.3 ± 1.7(XYZ-I-71) vs 10.1 ± 1.5 (Iri)ns 3.6 ± 0.4(XYZ-I-71)*** vs 10.1 ± 1.5 (Iri)	11.6 ± 1.1	8.7 ± 0.9 (XYZ-I-71) ns vs 11.6 ± 1.1 (Iri) 3.9 ± 0.5 (XYZ-I-73)*** VS 11.6 ± 1.1 (Iri)	9.5 ± 1.0	$7.7\pm {0.8}_{(\text{XYZ}-1-71)}^{\text{ns}}$ VS 9.5 ± 1.0 (Iri) 5.9 ± 0.7 (XYZ-I-73)* VS 9.5 ± 1.0 (Iri)

Data represent ± SEM, n = 3

^***(p = 0.001

^**p = 0.01

^*p = 0.05 ns = not significant) Iri=Irinotecan.