Table 2.

Summary of CTT results.

	Reliability		Construct validity							Ability to detect change over time
					Correlation with other COAs3					Standardized effect size3
	Cronbach’s alpha	ICC2	Item-to-Item correlation coefficients	Item-to-Scale correlation coefficients	MGC score	QMG score	MG ADL score	MG II—total score	MG QoL15r score	Worsened patients	Stable patients	Improved patients
	N=2001	N = 116	Range	Range						N = 13	N = 93	N = 78
Muscle weakness fatigability	0.89	0.88	0.35–0.94	0.58–0.71	0.56	0.41	0.68	0.42	0.71	0.31	−0.32	−1.04
Physical fatigue	0.97	0.89	0.48–0.94	0.61–0.89	0.38	0.36	0.49	0.38	0.68	0.30	−0.27	−0.86
Bulbar muscle weakness	0.91	0.83	0.37–0.93	0.55–0.75	0.57	0.26	0.57	0.29	0.53	0.08	−0.30	−0.70
Respiratory muscle weakness	0.88	0.81	0.80–0.86	0.71–0.79	0.41	0.32	0.54	0.28	0.59	0.32	−0.16	−0.49
Ocular muscle weakness	0.83	0.81	0.41–0.92	0.48–0.67	0.33	0.26	0.67	0.41	0.48	−0.05	−0.21	−0.55

¹Ns for all scales = 200 except Bulbar Muscle Weakness, which is N = 197. ²Intraclass correlation coefficient between screening and baseline, among stable patients according to PGIS. ³Effect size for participants according to change in the PGIS at Day 29. ICC, Intraclass correlation coefficient; MGC, MG composite; QMG, Quantitative MG; MG-ADL, MG activities of daily living; MGII, MG impairment index-total score; MG QOL15r, MG quality of life 14-item revised.