Central Illustration.

Social Determinants of Health and Cardio-Oncology

These social determinants of health (SDOH) domains have been shown to be integral to the development and progression of cardio-oncologic outcomes. Moreover, clonal hematopoiesis, as well as epigenetic (related to mitochondrial DNA copy number and DNA alterations) and cell signaling mechanistic pathways, which influence catecholamines and inflammatory cytokines, further link SDOH to cardio-oncology. It is imperative to consider the integration of SDOH into targeted interventions that encourage health equity within the field of cardio-oncology. The rightward arrow indicates the influence of adverse SDOH on biological pathways. The upward arrow indicates the integration of SDOH into cardio-oncologic care to impact cardio-oncology outcomes. CHIP = clonal hematopoiesis of indeterminate potential; ROS = reactive oxygen species.