Table 3.
Comparison of the characteristics of disease and patients undergoing amputation after limb-salvage surgery for extremity sarcomas
| Stojadinovic et al., 2001 | Smith et al., 2017 | Erstad et al., 2018 | Present Study | |
|---|---|---|---|---|
| Age (Median) | 39 | 61 | 52 | 44 |
| Amputation after LSS | 18 | 36 | 22 | 25 |
| Amputation decision for first recurrence | 18 (100.0) | 21 (58.3) | 18 (81.8) | 4 (16.0) |
| Tumor size | ||||
| <5 cm | 7 (38.9) | Nr | 4 (18.2) | 2 (8.0) |
| 5–10 cm | 5 (27.8) | Nr | 10 (45.5) | 14 (56.0) |
| >10 cm | 6 (33.3) | Nr | 7 (31.8) | 9 (36.0) |
| Nr | 0 (0.0) | 0 (0.0) | 1 (4.5) | 0 (0.0) |
| Median | Nr | 9.3 | Nr | 9 |
| Tumor grade | ||||
| Low grade | 0 (0.0) | 1 (2.8) | 1 (4.6) | 4 (16.0) |
| Intermediate grade | 0 (0.0) | 15 (41.7) | 2 (9.1) | 3 (12.0) |
| High grade | 18 (100.0) | 19 (52.7) | 16 (72.7) | 18 (72.0) |
| Nr | 0 (0.0) | 1 (2.8) | 3 (13.6) | 0 (0.0) |
| Tumor localization | ||||
| Upper extremity | 10 (55.6) | 23 (63.9) | 6 (27.3) | 6 (24.0) |
| Lower extremity | 7 (38.9) | 13 (36.1) | 14 (63.6) | 19 (76.0) |
| Trunk | 1 (5.5) | 0 (0.0) | 2 (9.1) | 0 (0.0) |
| Tumor margin | ||||
| Negative | 9 (50.0) | Nr | 10 (45.5) | 16 (64.0) |
| Positive | 9 (50.0) | 12 (54.5) | 9 (36.0) | |
| Tumor depth | ||||
| Superficial | 0 (0.0) | Nr | 5 (22.7) | 0 (0.0) |
| Deep | 18 (100.0) | 16 (72.7) | 25 (100.0) | |
| Nr | 0 (0.0) | 1 (4.6) | 0 (0.0) | |
| Metastasis before amputation | 3 (16.7) | Nr | 4/17 (23.5) | 13 (52.0) |
| Metastasis after amputation | 13 (72.2) | Nr | 17 (77.3) | 22 (88.0) |
| Amputation indication | ||||
| Oncological indication | 18 (100.0) | 36 (100.0) | 17 (77.3) | 18 (72.0) |
| Non-oncological indication | 0 (0.0) | 0 (0.0) | 5 (22.7) | 7 (28.0) |
| Post-amputation local recurrence | 1 (5.5) | Nr | 2/17 (11.8) | 0 (0.0) |
Nr: not recorded; LSS: limb-salvage surgery.