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Sensitivity to neutralization by the IgG1b12 MAb of parental and chimpanzee passaged isolates as measured on CD8 T-cell-depleted PHA-stimulated chimpanzee PBMC. (A) HIV-IIIB (●) and LAI/ch-Ma (○). (B) HAN2 (■) and HAN2/ch-in vivo (□). The TCID50 of the on human PBMC-grown virus stocks was first determined on the same CD8 T-cell-depleted chimpanzee PBMC. Depicted in the graph is the percent neutralization compared to that of untreated controls.
