TABLE 1.
ICs of HIV-1 isolates passaged through chimpanzee PBMC
| Virus | Neutralizing MAb, human sera, or sCD4 titer of the indicated virus isolate to:
|
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| sCD4 (μg/ml)a
|
MAbsa
|
Pooled anti-HIV-1-positive serab
|
||||||||||||
| IgG1b12 (μg/ml)
|
gp13 (μg/ml)
|
gp68 (μg/ml)
|
1577 (μg/ml)
|
HIVIG
|
Amshps
|
|||||||||
| IC50 | IC90 | IC50 | IC90 | IC50 | IC90 | IC50 | IC90 | IC50 | IC90 | IC50 | IC90 | IC50 | IC90 | |
| HAN2 | 51.9 | 98.6 | 41.8 | 69.2 | 40 | 78.3 | >50d | >50 | >65 | >65 | 41 | 22 | 39 | 19 |
| HAN2/ch-in vitro-p1 | 3.9 | 29.0 | 53.5 | 96.81 | 51.3 | >50 | >50 | >50 | NDc | ND | 63 | 22 | 64 | 17 |
| HAN2/ch-in vitro-p3 | 1.1 | 6.7 | 10.2 | 44.8 | 20.1 | >50 | >50 | >50 | ND | ND | 247 | 38 | 480 | 21 |
| HIVAms37 | 35.0 | 67.2 | 3.1 | 5.9 | ND | ND | ND | ND | ND | ND | 42 | 20 | 882 | 44 |
| HIVAms37/ch-in vitro | 1.27 | 3.9 | 0.54 | 15.0 | ND | ND | ND | ND | ND | ND | 43 | 20 | 904 | 24 |
| IIIB | 3.5 | 8.7 | 0.5 | 1.4 | 34 | 53 | 5.9 | 34.9 | 5.9 | 50.6 | 941 | 177 | 511 | 42 |
| LAI/ch-Ma | 2.3 | 7.2 | 0.9 | 3.5 | 50.4 | >50 | >50 | >50 | >65 | >65 | 182 | 21 | 32 | 14 |
| HAN2/ch-in vivo | 2.5 | 23.3 | 9.4 | 32.5 | >50 | >50 | >50 | >50 | >65 | >65 | 187 | 43 | 291 | 45 |
a
The 50 and 90% neutralization titers were determined by assaying p24 inhibition.
b
Reciprocal 50 and 90% neutralization titers.
c
ND, not done.
d
Instances in which no neutralization was observed with the highest concentration of MAb used are indicated with a “>” sign.