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Risk factors for metformin-associated lactic acidosis
|
Risk factors
|
Mechanism
|
| Kidney failure (any cause) | Reduced renal elimination of metformin[45] |
| Cimetidine | Reduced renal elimination of metformin[51] |
| Ribociclib | Reduced renal elimination of metformin[52] |
| Excessive alcohol consumption | Ethanol oxidation consumes nicotinamide adenine dinucleotides that are also required for lactate metabolism[50] |
