Table 2.
Showing the five variants of concerns and their mutations
|
WHO label
|
Pango lineage
|
GISAID clade
|
Nextstrain clade
|
Spike protein substitutions
|
First detected
|
WHO date of designation
|
| Alpha | B.1.1.7 | GRY | 201(V1) | Deletion 69-70, Deletion 144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H | United Kingdom | 18th December 2020 |
| Beta | B.1.351 | GH/501Y.V2 | 20H(V2) | D80A, D215G, DeletionL242, DeletionA243, DeletionL244, K417N, E484K, N501Y, D614G, A701V | South Africa | 18th December 2020 |
| Delta | B.1.617.2 | G/478K.V1 | 21A | T19R, T95I, G142D, Deletion156, Deletion157, R158G, L452R, T478K, D614G, P681R and D950N | India | VOI: 4th April, 2021 VOC: 11th May, 2021 |
| Gamma | P.1 | GR/501Y.V3 | 20J(V3) | L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I | Brazil | 11th January 2021 |
| Omicron | B.1.1.529 lineage | GR/484A | 21K | A76V, T95I, Y145del, G339D, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F, L212I, S371L, S373P, S375F, K417N. ORF1a: K856R, ORF1a: L2084I, ORF1a: A2710T, ORF1a: T3255I, ORF1a: P3395H, ORF1a: I3758V, ORF1b: P314L, ORF1b: I1566V, and ORF9b: P10S | Botswana and South Africa | 26th November 2021 |
WHO: World health organization; GISAID: Global initiative on sharing all influenza data; VOI: Variants of interest; VOC: Variants of concern.