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[Preprint]. 2024 Jun 25:2024.06.20.599943. [Version 1] doi: 10.1101/2024.06.20.599943

Figure 7: SOD1 silencing with di-siRNA rescued loss of synaptic markers in G93A mice.

Figure 7:

(A) Genotypes and treatment groups used to assess neuropathology. (B) Representative images and insets showing presynaptic marker synaptophysin and postsynaptic marker PSD-95 staining signal from layer V of primary motor cortex. (C) Representative images and insets showing synaptophysin and PSD-95 staining signal from anterior horn of the lumbar spinal cord. (D) Quantification of PSD-95 in layer V of primary motor cortex. (E) Quantification of PSD-95 in anterior horn. (F) Quantification of synaptophysin in layer V of primary motor cortex (G) Quantification of synaptophysin in the anterior horn. Scale bar=100 μm, Scale bar=10 μm (inset). Data in the bar graphs are shown as mean ±SEM n=2 per group.