Figure 2: Site model analysis of adaptive kinetochore protein evolution.
(A) Kinetochore proteins for which the null M1 site model is rejected harbor elevated dN/dS (ω) ratios compared to proteins for which the M1 model cannot be rejected (p < 2x10-16). (B) Boxplot representing the dN/dS (ω) ratios (y-axis) of kinetochore proteins based on their position and function in the kinetochore (x-axis). CCAN and outer kinetochore proteins have significantly higher dN/dS (ω) ratios compared to the SAC and other kinetochore proteins.
