Figure 6. BI extends overall survival in both chemoresistant and chemo-sensitive models and dramatically enhances chemotherapy response in the chemo-sensitive model.

(A) Survival curves of KPCA tumor-bearing mice treated with PBS, carboplatin, BI, or BI+carboplatin as indicated. The numbers of mice are PBS n=14, carboplatin n=10, BI n=20, BI+carboplatin n=15. The graph is a combination of three independent experiments. (B) survival curves of BPPNM tumor-bearing mice treated with BI and carboplatin as indicated. The numbers of mice are PBS n=14, carboplatin n=20, BI n=15, BI+carboplatin n=14. The graph is a combination of three independent experiments. Log-rank test was used.