Table 2.
Age-adjusted Mortality Rates Among CHeCS CHB Patients Compared With the MCOD Data by Cause of Death, 2006–2014
| Annual Mortality Rate, per 100000 Person-Years | ||||
|---|---|---|---|---|
|
| ||||
| Cause of Death | CHeCS CHB (n = 492)a | MCOD (n = 2 464 447)b | Relative Risk | (95% CI)* |
| Hepatitis B virus | 299.105 | 0.761 | 392.7 | (374.9–411.4) |
| Hepatitis-related (other) | 17.901 | 0.102 | 173.3 | (152.8–196.7) |
| HIV | 193.617 | 4.518 | 42.96 | (42.14–43.79) |
| Liver cancer | 281.230 | 9.480 | 29.39 | (29.00–29.78) |
| Any liver-related | 716.571 | 44.876 | 15.91 | (15.81–16.01) |
| Liver, non–alcohol-related | 415.891 | 28.298 | 14.66 | (14.55–14.78) |
| Hepatitis C virus | 42.785 | 7.228 | 5.900 | (5.805–5.997) |
| Liver, alcohol-related | 24.719 | 8.994 | 2.746 | (2.703–2.790) |
| Genitourinary | 233.308 | 114.382 | 2.021 | (2.011–2.030) |
| Overall | 1948.137 | 1041.162 | 1.854 | (1.851–1.857) |
| Other causes | 639.560 | 374.191 | 1.689 | (1.685–1.694) |
| Digestive, non-liver | 80.506 | 49.860 | 1.601 | (1.589–1.612) |
| Diabetes | 159.329 | 100.396 | 1.575 | (1.567–1.584) |
| Malignancy, non-liver | 385.194 | 265.196 | 1.445 | (1.441–1.450) |
| Mental and behavioral disorders | 236.007 | 206.219 | 1.128 | (1.124–1.132) |
| Circulatory | 456.327 | 573.388 | 0.788 | (0.786–0.790) |
| Injury/Trauma | 75.569 | 95.927 | 0.784 | (0.779–0.788) |
| Respiratory | 198.685 | 269.264 | 0.730 | (0.727–0.733) |
Abbreviations: CHB, chronic hepatitis B; CHeCS, Chronic Hepatitis Cohort Study; CI, confidence interval; HIV, human immunodeficiency virus; MCOD, Multiple Cause of Death.
a
Total number of deaths equals 492; total CHB deaths with a death certificate were 409. Cases could have >1 listed cause of death. A mean mortality rate from 2006–2014 was calculated for CHeCS and MCOD data. CHeCS data were age-standardized to the census population in 2010.
b
Average deaths per year, 2006–2014, age-standardized to the 2010 U.S. census population.
*
P < .05 for all variables.