Skip to main content
[Preprint]. 2024 Jun 27:rs.3.rs-4559940. [Version 1] doi: 10.21203/rs.3.rs-4559940/v1

Figure 4.

Figure 4

Microglial Slc11a2 knockdown worsens hyperactivity in a novel environment in male APP/PS1 mice at 12–15 months.

A-B) Elevated zero maze. A Total distance traveled (m) in control WT, control APP/PS1, Slc11a2KD WT, and Slc11a2KD APP/PS1 male mice. B Total percent time spent in open arms. C-D) Open field locomotor activity assay. C Total distance traveled (cm). D Total percent time spent in the center. E-G) Exploratory Y-maze. E Total distance traveled (m). F Total number of different arm entries. G Total percent alternation. Two-way ANOVA, *p<0.05, ***p<0.001 effect of APP/PS1 genotype. #p<0.05 Slc11a2KD vs. Control. ns = not significant. Data represent the mean ± S.E.M of 11–15 male mice per group. Statistical outliers were removed using the Grubb’s test.