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Lead T6Is and clinically relevant SERMs and SERDs inhibit WT and Y537S ERα-Coactivator binding. Clinically relevant A) SERD and B) SERM inhibition curves with WT-SRC3 binding. C) Rad1901 and T6Is inhibition curves for WT-SRC3 binding. D-F) Same as A-C, but with Y537S-SRC3 binding. Data are shown as the mean ± s.d.
