[Preprint]. 2024 Jun 25:rs.3.rs-4150225. [Version 1] doi: 10.21203/rs.3.rs-4150225/v1

Table 1.

Demographics for fMRI and EEG datasets

Full dataset
All participants n = 5306		HCs = 3509	MCI = 517	AD = 828	bvFTD = 463
fMRI dataset
Variable		HCs Non-LAC n = 967 LAC n = 477	MCI Non-LAC n = 215 LAC n = 169	AD Non-LAC n = 214 LAC n = 505	bvFTD Non-LAC n = 190 LAC n = 216	Statistics Non-LAC vs. LAC	Post-hoc comparisons
Sex (F:M)	Non-LAC	470:497	114:101	112:102	98:92	χ² = 2.19	HC-MCI: p > 0.05
						p = 0.533	HC-AD: p > 0.05
							HC-bvFTD: p > 0.05
	LAC	261:216	84:85	262:243	105:111	χ² = 2.76	HC-MCI: p > 0.05
						p = 0.429	HC-AD: p > 0.05
							HC-bvFTD: p > 0.05
Age (years)	Non-LAC	53.55	59.62	76.59	73.14	F = 3.13	HC-MCI: p > 0.05
		(13.43)	(8.77)	(9.35)	(8.56)	p = 0.47	HC-AD: p > 0.05
						np² = 0.02	HC-bvFTD: p > 0.05
Range: [22–91]	LAC	65.34	66.53	77.52	73.15	F = 3.62	HC-MCI: p > 0.05
		(11.44)	(8.18)	(9.35)	(8.76)	p = 0.45	HC-AD: p > 0.05
						np² = 0.02	HC-bvFTD: p > 0.05
Years of Education	Non-LAC	13.15	14.15	13.12	11.16	F = 2.19	HC-MCI: p > 0.05
		(5.41)	(3.41)	(5.34)	(3.56)	p = 0.49	HC-AD: p > 0.05
						np² = 0.02	HC-bvFTD: p > 0.05
Range: [0 – 25]	LAC	12.11	11.52	8.89	7.89	F = 1.31	HC-MCI: p > 0.05
		(3.39)	(6.32)	(4.34)	(3.36)	p = 0.68	HC-AD: p > 0.05
						np² = 0.01	HC-bvFTD: p > 0.05
EEG dataset
		HCs Non-LAC n = 569 LAC n = 1486	MCI LAC n = 133	AD LAC n = 108	bvFTD LAC n = 57	Statistics Non-LAC vs. LAC	Post-hoc comparisons
Sex (F:M)	Non-LAC	470:99	-	-	-	χ² = 64.62	-
Sex (F:M)	Non-LAC					p < 0.001*
	LAC	954:532	111:22	85:23	39:18	χ² = 28.05	HC-MCI: p > 0.05
						p < 0.001*	HC-AD: p > 0.05
							HC-bvFTD: p > 0.05
Age (years)	Non-LAC	58.98	-	-	-	t = 4.21	-
		(12.03)				p = 0.07
						np² = 0.02
Range: [21–92]	LAC	66.74	62.54	78.62	71.05	F = 7.62	HC-MCI: p > 0.05
		(13.94)	(9.98)	(8.34)	(9.34)	p < 0.001*	HC-AD: p > 0.05
						np² = 0.07	HC-bvFTD: p > 0.05
Years of Education	Non-LAC	14.85 (4.91	-	-	-	t = 3.54	-
						p = 0.08
						np² = 0.01
Range: [0 – 24]	LAC	13.92	8.12	10.75	14.38	F = 6.31	HC-MCI: p > 0.05
		(3.39)	(4.34)	(6.32)	(5.49)	p < 0.001*	HC-AD: p > 0.05
						np² = 0.06	HC-bvFTD: p > 0.05

Results are presented as mean (SD). Asterisks (*) indicate an alpha level of p < 0.05. Demographic data comparing non-LAC and LAC groups were assessed using unpaired t-tests, while data for pathological groups were analyzed using ANOVAs followed by Tukey post-hoc pairwise comparisons, except for sex, which was analyzed using Pearson’s chi-squared (χ²) test. Effect sizes were calculated using partial eta squared (ηp²). Abbreviations: HC = healthy control, MCI = mild cognitive impairment, AD = Alzheimer’s disease, bvFTD = behavioral variant frontotemporal dementia.