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Model of AAV DNA replication. The boxed region illustrates the steps involved in the terminal resolution of AAV viral ends. In vitro, Rep68 is necessary and sufficient for both the site-specific endonuclease and helicase activities required for terminal resolution. The viral 3′ end is indicated with an arrow. Circles depict Rep covalently attached to the viral 5′ end at the terminal resolution site (trs).
