Table 3. MIPS2673 effectiveness against a panel of drug-resistant P. falciparum strains*.
| P. falciparum strain | Sensitivity profile | EC50 (nM)† | Fold shift in EC50 relative to | |
|---|---|---|---|---|
| NF54 | Dd2 | |||
| NF54 | Sensitive | 237 | 1.0 | |
| K1 | Decreased sensitivity to chloroquine | 278 | 1.2 | |
| 7G8 | Decreased sensitivity to chloroquine | 293 | 1.2 | |
| TM90C2B | Decreased sensitivity to atovaquone | 194 | 0.8 | |
| Cam3.1 | Decreased sensitivity to artemisinin | 244 | 1.0 | |
| Dd2 | Decreased sensitivity to chloroquine | 220 | 0.9 | 1.0 |
| Dd2 DDD107498 | Decreased sensitivity to eEF2 inhibitor, DDD107498 | 211 | 1.0 | |
| Dd2 MMV390048 | Decreased sensitivity to PI4K inhibitor, MMV390048 | 164 | 0.7 | |
| Dd2 DSM265 | Decreased sensitivity to DHODH inhibitor, DSM265 | 183 | 0.8 | |
| Dd2 GNF156 | Decreased sensitivity to GNF156 | 195 | 0.9 | |
| Dd2 ELQ300 | Decreased sensitivity to cyt bc1 inhibitor, ELQ300 | 174 | 0.8 | |
*
72 hr [3H]-hypoxanthine incorporation assay.
†
Mean values from two biological replicates.