Search	Query	Records retrieved
S1	(MH “Lysosomal Storage Diseases+”) or (MH “Peroxisomal Disorders+”)	3531
S2	TI(leukodystrophy or metachromatic or Krabbe or adrenoleukodystrophy) or AB(leukodystrophy or metachromatic or Krabbe or adrenoleukodystrophy)	788
S3	S1 or S2	3972
S4	AB(patient or patients or participant or participants or family or families or mother or mothers or father or fathers or parents or grandparent or grandparents or grandfather or grandfathers or grandmother or grandmothers or child or children or sibling or siblings or carer or carers or caregiver or caregivers)	2,477,792
S5	S3 and S4	1955
S6	AB(life or living or well-being or experience* or care or challeng* or advantag* or disadvantages or attitude or emotions or stress or frustration or satisfact* or dissatisfact*)	1,731,483
S7	(MH “Gene Therapy”) or (MH “Hematopoietic Stem Cell Transplantation”) or (MH “Bone Marrow Transplantation+“) or AB(“gene therapy” or “hematopoietic stem cell transplantation” or “bone marrow transplantation” or “cord blood stem cell transplantation”)	21,668
S8	S6 or S7	1,747,988
S9	S5 and S8	736