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. 2024 Jul 5;10(8):e1674. doi: 10.1097/TXD.0000000000001674

FIGURE 1.

FIGURE 1.

IDO+ glomerular endothelial cells. A, Representative IMC images showing CD31 staining and IDO staining at week 4 and week 24. B, Bar graph showing the amount of IDO– and IDO+ glomeruli per patient in IMC for patient 1005, 1006, and 1065. C, Plot showing the percentage (%) of IDO+ pixels per glomeruli at 4 wk and 24 wk/5 y for the group that has glomerulitis at 24 wk/5 y and the glomerulitis– group at 24 wk. Significance was calculated between the blue (IDO–) and red (IDO+) glomeruli. Lines indicate medians (4 wk = 2.7%, 24 wk/5 y glomerulitis+ = 5.99, 24 wk/5 y glomerulitis+IDO+ = 20.5%, 24-wk glomerulitis– = 3.5). Each dot represents a glomeruli, the unique shape identifies the patient. D, Representative IHC stain for IDO in patient 1065. E, Representative IMC images showing DNA stain and merged images of IDO/CD31, IDO/HLA-DR, and HLA-DR/CD31 in a glomerulitis+IDO+ glomerulus. IDO, indoleamine 2,3 dioxygenase; IHC, immunohistochemistry; IMC, imaging mass cytometry.