FIG. 6.

Regulation by Murabutide of CD4 and CCR5 membrane expression in MDMs. Following 24 h of culture in the absence or presence of Murabutide, MDMs were stained with CD4 or CCR5 MAbs and with isotype-matched control antibodies. Histograms from one representative experiment showing the percentage of positive cells and the MFI for CD4 and CCR5 (shaded area), as well as the staining profile obtained with isotype-matched antibodies (open area) are presented in panel A. The data shown in panels B and C are means ± SEMs of five separate experiments reflecting the percentage of positive cells (B) and the MFI (C) in untreated (Medium) or Murabutide-treated cultures. ∗, expression of CD4 and CCR5 significantly reduced compared with that in unstimulated cells (P < 0.05).