Table 1.

Adverse events

	GRADE 0	GRADE 1	GRADE 2	GRADE 3	GRADE 4	GRADE 5
Arterial hypertension	599 (72.8%)	65 (7.9%)	107 (13.0%)	52 (6.3%)	0 (0.0%)	0 (0.0%)
Fatigue	609 (74.0%)	145 (17.6%)	55 (6.7%)	14 (1.7%)	0 (0.0%)	0 (0.0%)
Decreased appetite	647 (78.6%)	112 (13.6%)	48 (5.8%)	16 (1.9%)	0 (0.0%)	0 (0.0%)
Proteinuria	579 (70.3%)	102 (12.4%)	85 (10.3%)	57 (6.9%)	0 (0.0%)	0 (0.0%)
Diarrhea	756 (91.9%)	48 (5.8%)	15 (1.8%)	4 (0.5%)	0 (0.0%)	0 (0.0%)
Hypothyroidism	779 (94.6%)	14 (1.7%)	27 (3.3%)	3 (0.4%)	0 (0.0%)	0 (0.0%)
Immunotoxicity	717 (87.1%)	54 (6.6%)	27 (3.3%)	21 (2.5%)	4 (0.5%)	0 (0.0%)
Other	659 (80.1%)	49 (5.9%)	57 (6.9%)	48 (5.8%)	9 (1.1%)	1 (0.1%)