Table 2.
Temporal linear trends in selected miRNAs prior to ovarian cancer diagnosis compared to differential expression results observed in comparison between ovarian cancer cases and controls in original paper by Elias et al. (eLife 2017).
| miRNA | Elias et al. | Our study | |||
|---|---|---|---|---|---|
| log2FC | p-value | beta | p-value | Interpretation | |
| miR-200c-3p | 1.56 | 0.000 | 0.08 | 0.27 | No change over time |
| miR-320d | 1.06 | 0.000 | 0.01 | 0.88 | No change over time |
| miR-320c | 0.79 | 0.000 | 0.02 | 0.78 | No change over time |
| miR-200a-3p | 1.03 | 0.000 | 0.15 | 0.04 | Concordant and significant trend |
| miR-1307–5p | 0.50 | 0.000 | -0.04 | 0.59 | No change over time |
| miR-1246 | 1.10 | 0.001 | 0.13 | 0.08 | Concordant and non-significant trend |
| miR-203a-3p | 1.05 | 0.001 | 0.12 | 0.11 | Concordant and non-significant trend |
| miR-450b-5p | 0.87 | 0.002 | 0.06 | 0.44 | No change over time |
| miR-23b-3p | 0.60 | 0.003 | 0.14 | 0.07 | Concordant and non-significant trend |
| miR-32–5p | 0.56 | 0.004 | 0.08 | 0.32 | No change over time |
| miR-335–5p | 0.48 | 0.004 | -0.02 | 0.80 | No change over time |
| miR-29a-3p | 0.48 | 0.011 | 0.05 | 0.50 | No change over time |
| miR-92a-3p | -0.21 | 0.126 | -0.03 | 0.71 | No change over time |
| miR-150–5p | 0.04 | 0.883 | -0.01 | 0.91 | No change over time |
miRNAs were considered concordant if they exhibited similar increase/decrease over time prior to diagnosis (linear regression beta coefficient and p-value) when compared to up-/downregulation (log2 fold-change; log2FC) reported in the Elias paper. Beta coefficients close to 0 (-0.1 < beta < 0.1) were interpreted as a lack of temporal trend.