Skip to main content
. 2024 May 15;131(1):63–76. doi: 10.1038/s41416-024-02710-x

Fig. 4. Lack of CXCR2 in hematopoietic myeloid cells suppresses CRC tumor growth and metastasis.

Fig. 4

a Scheme of BM transfer experiments. Wild-type recipient hosts were sub-lethally irradiated and then reconstituted with wild-type BM (WT > WT mice) or Cxcr2−/− BM (Cxcr2−/− > WT mice). b PCR analysis of wild-type (561 kb) and mutated allele (160 kb) of Cxcr2. p.c., positive control. n.c. negative control. c Tumor growth curves of transplanted MC38 tumors in WT > WT mice and Cxcr2−/− > WT mice. Bars, mean ± SEM (Student’s t test; *P < 0.05). n = 5 mice for each group. d Representative macroscopic views of transplanted MC38 tumors in WT > WT mice and Cxcr2−/−> WT mice. e Tumor weight of transplanted MC38 tumors in WT > WT mice and Cxcr2−/−>WT mice on day 28 post-inoculation. *P < 0.05 by Student’s t test. f Quantification of liver metastatic lesions (photon counts). Bars, mean ± SEM (Mann–Whitney U test; *P < 0.05 and **P < 0.01). n = 6 mice for each group. g Representative in vivo bioluminescence images of MC38-luc liver metastases in WT > WT mice and Cxcr2−/− > WT mice. h Liver weight of WT > WT mice and Cxcr2−/− > WT mice on day 21 post-injection. *P < 0.05 by Student’s t test.