Table 3.
Impact of the sex and mutated allele length on the AO in patients, analyzed by two-way ANOVA.
| Impact of expanded allele and sex on age at onset in HD | ||||||
|---|---|---|---|---|---|---|
| Factor | DF | Type II SS | Mean square | F value | P-value | N |
| (A) Whole population | ||||||
| Mutated allele | 41 | 244.2525553 | 5.9573794 | 155.63 | < 0.0001 | 3723 |
| Sex | 1 | 0.4797997 | 0.4797997 | 12.53 | 0.0004 | |
| Mutated allele*sex interaction | 32 | 1.3539487 | 0.0423109 | 1.11 | 0.3131 | |
| (B) Mutated allele of (CAG)n = 40–45 | ||||||
| Mutated allele | 5 | 35.81407630 | 7.16281526 | 204.28 | < 0.0001 | 2617 |
| Sex | 1 | 0.42192903 | 0.42192903 | 12.03 | 0.0005 | |
| Mutated allele*sex interaction | 5 | 0.22615282 | 0.04523056 | 1.29 | 0.2653 | |
| (C) Normal allele of (CAG)n > 17 | ||||||
| Mutated allele | 36 | 119.6907953 | 3.3247443 | 81.97 | < 0.0001 | 1802 |
| Sex | 1 | 0.5230997 | 0.5230997 | 12.90 | 0.0003 | |
| Mutated allele*sex interaction | 25 | 1.2288383 | 0.0491535 | 1.21 | 0.2157 | |
| (D) Normal allele of (CAG)n ≤ 17 | ||||||
| Mutated allele | 36 | 122.7888247 | 3.4108007 | 95.85 | < 0.0001 | 1841 |
| Sex | 1 | 0.0729239 | 0.0729239 | 2.05 | 0.1525 | |
| Mutated allele*sex interaction | 24 | 1.3786835 | 0.0574451 | 1.61 | 0.0303 | |
| (E) Normal allele of (CAG)n > 17 and mutated allele of (CAG)n = 40–45 | ||||||
| Mutated allele | 5 | 14.95028510 | 2.99005702 | 77.82 | < 0.0001 | 1273 |
| Sex | 1 | 0.59534683 | 0.59534683 | 15.50 | < 0.0001 | |
| Mutated allele*sex interaction | 5 | 0.05386317 | 0.01077263 | 0.28 | 0.9240 | |
| (F) Normal allele of (CAG)n ≤ 17 and mutated allele of (CAG)n = 40–45 | ||||||
| Mutated allele | 5 | 20.42851681 | 4.08570336 | 129.15 | < 0.0001 | 1285 |
| Sex | 1 | 0.03410713 | 0.03410713 | 1.08 | 0.2993 | |
| Mutated allele*sex interaction | 5 | 0.27334713 | 0.05466943 | 1.73 | 0.1252 | |
The analyses were carried (A) across the entire study group, and in the following subgrups: (B) in subjects with the mutated allele of (CAG)n = 40–45 (C) in subjects with the normal allele of (CAG)n > 17 (D) in subjects with the normal allele of (CAG)n ≤ 17 (E) in subjects with the mutated allele of (CAG)n = 40–45 and normal allele of (CAG)n > 17 (F) in subjects with the mutated allele of (CAG)n = 40–45 and normal allele of (CAG)n ≤ 17.