Table 4.
Comparison of demographic and clinical manifestations by age at onset.
| Qualitative Variables | Age at Onset |
||||
|---|---|---|---|---|---|
| <18 |
18–50 |
≥50 |
P-value1 | ||
| N (%) | |||||
| Sex |
Female | 92(77.3 %) | 1361(75.6 %) | 30(65.2 %) | 0.241 |
| Male |
27(22.7 %) |
439(24.4 %) |
16(34.8 %) |
||
| Parental Consanguinity |
Yes | 31(26.1 %) | 343(19.1 %) | 6(13.0 %) | 0.095 |
| No |
88(73.9 %) |
1457(80.9 %) |
40(87.0 %) |
||
| MS Phenotype |
RR | 101(84.9 %) | 1451(81.2 %) | 30(65.2 %) |
<0.001 |
| SP | 16(13.4 %) | 240(13.4 %) | 6(13.0 %) | ||
| PP | 2(1.7 %) | 84(4.7 %) | 10(21.7 %) | ||
| PR |
0(0.0 %) |
12(0.7 %) |
0(0.0 %) |
||
| Number of Affected Relatives | 1 | 84(70.6 %) | 1400(77.8 %) | 37(80.4 %) | 0.170 |
| >1 | 35(29.4 %) | 400(22.2 %) | 9(19.6 %) | ||
| Hospitalization due to MS |
0 | 32(26.9 %) | 507(28.4 %) | 24(52.2 %) |
0.002 |
| ≥1 |
87(73.1 %) |
1280(71.6 %) |
22(47.8 %) |
||
| Conversion to SPMS | Yes | 16(13.9 %) | 254(14.6 %) | 4(8.7 %) | 0.527 |
| No | 99(86.1 %) | 1488(85.4 %) | 42(91.3 %) | ||
| Quantitative Variables | Mean (SD) | P-value2 | ||
|---|---|---|---|---|
| Age | 25.59(7.23) | 37.16(8.70) | 57.46(4.61) | <0.001 |
| Age at Onset | 14.76(2.33) | 29.11(7.57) | 49.85(7.35) | <0.001 |
| Age at Diagnosis | 15.10(2.21) | 30.18(7.59) | 54.54(3.96) | <0.001 |
| Latency Period | 0.34(0.95) | 1.08(2.62) | 4.70(6.98) | <0.001 |
| Number of Affected Relatives | 1.36(0.65) | 1.30(0.67) | 1.20(0.40) | 0.340 |
| EDSS Score | 1.94(1.76) | 2.19(1.92) | 3.08(1.73) | 0.002 |
N: Number, SD: Standard Deviation, FMS: Familial MS, RR: Relapsing Remitting, SP: Secondary Progressive, PP: Primary Progressive, RP: Relapsing Progressive, EDSS: Expanded Disability Status Scale.
P-value1: P-value computed by Chi-square test, P-value2: P-value computed by independent t-test.