Date	Event	Description
11 June 2014	New citation required and conclusions have changed	Summary of most important changes in the update: The search for eligible studies was updated to July 2013. One new randomised controlled trial (RCT) addressing children with acute myeloid leukemia was included (this type of tumour was not addressed in the earlier versions of this review). For the risk of bias assessment we used the most recent recommendations of the Childhood Cancer Group. All RCTs (including those already included in earlier versions of the review) were scored using the new risk of bias criteria.
11 June 2014	New search has been performed	The search for eligible studies was updated to July 2013.