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. 2024 Jul 9;22:403. doi: 10.1186/s12951-024-02697-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — iPSC-NSCs-Exos suppress pyroptosis in BV2 cells by delivering let-7b-5p in vitro. (A) Volcano plot of differential expression miRNAs in iPSC-NSCs-Exos compared with iPSC-NSCs; (B) qRT-PCR quantitative study of the top 10 significantly differential expression miRNAs (Log2FC > 1) between iPSC-NSCs-Exos and iPSC-NSCs; (C)Transfection efciency of let-7b-5p overexpression and knockdown in iPSC-NSCs (n = 5 per group); (D) The relative expression of let-7b-5p in exosomes derived from iPSC-NSCs in indicated groups (n = 5 per group); (E) The relative expression of let-7b-5p in BV2 cells administered with miR-NC^OE-Exos, let-7b-5p^OE-Exos, miR-NC^KD-Exos and let-7b-5p^KD-Exos (n = 5 per group); (F-G) Representative immunofluorescence staining images of GSDMD/Caspase-1 (red) and IBA-1 (green) in indicated groups; (H-I) Quantifcation of fuorescence of GSDMD and Caspase-1 intensity in indicated groups. *P < 0.05; **P < 0.01; ***P < 0.001 (n = 3 per group)