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. Author manuscript; available in PMC: 2024 Jul 9.
Published in final edited form as: ACS Appl Mater Interfaces. 2021 Jun 14;13(35):41424–41434. doi: 10.1021/acsami.1c05209

Figure 1.

Figure 1.

ChemoFilter concept and material design. (a) Schematic of clinical use of ChemoFilter in the treatment of HCC. Excess chemotherapeutic agents not absorbed by the tumor are captured by the ChemoFilter before they enter systemic circulation. (b) Doxorubicin intercalates into DNA and causes cell death. (c) 3D cubic lattice fabricated via digital light processing printing (left). A scanning electron microscope (SEM) image (top view) of the same cubic lattice (right). (d) Two synthetic approaches to coating 3D-printed polyacrylate materials with DNA. Top row: Coating of DNA followed by UVC cross-linking. Bottom row: Installation of surface amine groups followed by electrostatic-interaction assisted DNA coating and then subsequent UVC cross-linking.