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. 2024 Jul 8;20(1):2357924. doi: 10.1080/21645515.2024.2357924

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© 2024 GSK. Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 3. — Real-world evidence of the effectiveness, impact, and safety of 4CMenB.

A. Vaccine effectiveness and vaccine impact against invasive meningococcal serogroup B (MenB) disease.

B. Safety profile of 4CMenB.

C. Effectiveness against non-B meningococcal disease and gonococcal disease.

4CMenB, 4-component MenB vaccine; AE, adverse event; AEFI, AE following immunization; aIRR, adjusted IRR; CI, confidence interval; IMD, invasive meningococcal disease; IRR, incidence rate ratio; MenACWY, meningococcal serogroup ACWY vaccine; MenB, meningococcal serogroup B; MenB-FHbp, MenB-factor H binding protein vaccine; MenW, meningococcal serogroup W; MSM, men who have sex with men; NIP, national immunization program; OMV, outer membrane vesicles; OR, odds ratio; PLWH, people living with HIV; RIP, regional immunization program; SAE, serious AE; SLSJ, Saguenay-Lac-Saint-Jean; SmPC, summary of product characteristics; UK, United Kingdom; US, United States; VE, vaccine effectiveness.