Table 2.
Association between 10-year average CO exposure with a 5-year lag time and Parkinson’s disease.
| Odds ratio (95% CI) | ||||
|---|---|---|---|---|
|
|
||||
| Residence | Cases/controls | Unadjusted | Model1a | Model2b |
|
| ||||
| Continuous CO (ppb)c | 688/851 | 1.07 (1.01, 1.13) | 1.08 (1.02, 1.14) | 1.09 (1.03, 1.16) |
| T1 (0.01–2.87) | 242/343 | Reference | Reference | Reference |
| T2 (2.88–9.06) | 242/292 | 1.17 (0.93, 1.49) | 1.24 (0.97, 1.59) | 1.38 (1.07, 1.77) |
| T3 (9.07–368.00) | 204/216 | 1.34 (1.04, 1.72) | 1.40 (1.07, 1.83) | 1.58 (1.20, 2.10) |
| p-trendd | 0.06 | 0.05 | 0.02 | |
|
| ||||
| Workplace | ||||
|
| ||||
| Continuous CO (ppb)c | 336/309 | 1.02 (0.97, 1.08) | 1.05 (0.99, 1.12) | 1.06 (1.00, 1.13) |
| T1 (0.01–2.87) | 70/73 | Reference | Reference | Reference |
| T2 (2.88–9.06) | 97/97 | 1.04 (0.68, 1.61) | 1.21 (0.76, 1.91) | 1.27 (0.79, 2.04) |
| T3 (9.07–368.00) | 169/139 | 1.27 (0.85, 1.89) | 1.72 (1.12, 2.65) | 1.91 (1.22, 3.00) |
| p-trendd | 0.18 | 0.01 | <0.01 | |
a
Adjusted for age, race, sex, education, and study wave.
b
Adjusted as in model 1 plus smoking status and pesticide exposure.
c
Change per interquartile range (IQR) of 10.27 ppb.
d
Based on linear model through the tertile midpoints.