Table 1.

Dual point contrast and positron emission tomography across different tumor histopathological types

Clinical reporting on PET	Subtracted T1 contrast images matched PET uptake	75-min delayed T1 contrast grayscale inverted images matched PET AC images	DWI grayscale inverted images matched PET AC images	Comments
Radiation necrosis without recurrence [Figure 5]	Matched	Matched	Matched	DWI and Del-CE can be surrogate markers for FDG and amino acid PET in this scenario
High-grade glioma - with recurrence [Figure 6]	Matched	Matched	Matched	DWI and Del-CE can be surrogate markers for FDG and amino acid PET in this scenario
Low grade - enhancing glioma [Figure 7]	Matched	Matched	Mismatched	FDG and DWI matched as both show less uptake and signal in this scenario DWI did not correlate with amino acid PET in this scenario amino acid PET is sensitive irrespective of tumor grade unlike DWI Del-CE was noted in tumor uptake area of both FDG and amino acid PET Del-CE can be a marker for amino acid PET also
Low grade - nonenhancing glioma [Figure 8]	Mismatched	Mismatched	Mismatched	Both DWI and Del-CE did not correlate with amino acid PET in this scenario
Low-grade melanoma [Figure 9]	Matched	Matched	Mismatched	DWI no signal but Del-CE and PET showed uptake as lesion was T1 hyperintense, and both FDG and amino acid PET uptake in this scenario

DWI: Diffusion-weighted imaging, PET: Positron emission tomography, AC: Attenuation-corrected, FDG: Fluorodeoxyglucose, Del-CE: Del-Contrast enhanced