Table 2:
Patient demographics and clinical characteristics by AFRS disease severity (N = 210)
| Patient characteristic | Severity of AFRSa | |||
|---|---|---|---|---|
| Overall N = 210 (100%) | Non-severe N = 116 (55.2%) | Severe N = 94 (44.8%) | Chi-square p value | |
| Age at index, mean (SD) | 48.7 (15.8) | 50.3 (15.3) | 46.7 (16.3) | 0.11b |
| Age at index, median (Q1–Q3) | 49 (35, 60) | 50.5 (39, 62) | 46.5 (33, 59) | 0.11c |
| Age at index, n (%) | ||||
| 18–35 | 54 (25.7) | 23 (19.8) | 31 (33.0) | 0.19 |
| 36–50 | 58 (27.6) | 35 (30.2) | 23 (24.5) | |
| 51–65 | 66 (31.4) | 39 (33.6) | 27 (28.7) | |
| ≥ 65 | 32 (15.2) | 19 (16.4) | 13 (13.8) | |
| Age at index, n (%) | ||||
| 18–40 | 64 (30.5) | 30 (25.9) | 34 (36.2) | 0.11 |
| ≥ 41 | 146 (69.5) | 86 (74.1) | 60 (63.8) | |
| Gender, n (%) | ||||
| Female | 105 (50.0) | 54 (46.6) | 51 (54.3) | 0.27 |
| Male | 105 (50.0) | 62 (53.5) | 43 (45.7) | |
| Race/Ethnicity, n (%) | ||||
| Non-Hispanic White | 100 (47.6) | 61 (52.6) | 39 (41.5) | 0.13 |
| Black | 55 (26.2) | 22 (19.0) | 33 (35.1) | |
| Asian | 21 (10.0) | 12 (10.3) | 9 (9.6) | |
| Hispanic | 21 (10.0) | 13 (11.2) | 8 (8.5) | |
| Other | 13 (6.2) | 8 (6.9) | 5 (5.3) | |
| Medicaid status, n (%) | ||||
| Yes | 10 (4.8) | 3 (2.6) | 7 (7.5) | 0.11 |
| No | 200 (95.2) | 113 (97.4) | 87 (92.6) | |
| Neighborhood median household income, median (Q1–Q3) | 92,116 (70,919–126,028) | 96,801 (75,184.5–130,283.5) | 90,619 (60,643–117,745) | 0.14c |
| Neighborhood median household income, n (%) | ||||
| < $75,000 | 61 (29.1) | 28 (24.1) | 33 (35.1) | 0.27 |
| $75,000–$99,999 | 58 (27.6) | 35 (30.2) | 23 (24.5) | |
| $100,000–$129,999 | 45 (21.4) | 24 (20.7) | 21 (22.3) | |
| > $130,000 | 46 (21.9) | 29 (25.0) | 17 (18.1) | |
| Neighborhood median education, n (%) | ||||
| High school and below | 15 (7.1) | 7 (6.0) | 8 (8.5) | 0.49 |
| Some college and above | 195 (92.9) | 109 (94.0) | 86 (91.5) | |
| NDI, n (%) | ||||
| Q1 (least deprived) | 75 (25.7) | 48 (41.4) | 27 (28.7) | 0.09 |
| Q2 | 52 (24.8) | 31 (26.7) | 21 (22.3) | |
| Q3 | 33 (15.7) | 17 (14.7) | 16 (17.0) | |
| Q4 | 30 (14.3) | 13 (11.2) | 17 (18.1) | |
| Q5 (most deprived) | 20 (9.5) | 7 (6.0) | 13 (13.9) | |
| Healthy places index, n (%) | ||||
| Q1 (least advantaged) | 12 (5.7) | 6 (5.2) | 6 (6.4) | 0.11 |
| Q2 | 27 (12.9) | 11 (9.6) | 16 (17.0) | |
| Q3 | 43 (20.6) | 19 (16.5) | 24 (25.5) | |
| Q4 | 61 (29.2) | 40 (34.8) | 21 (22.3) | |
| Q5 (most advantaged) | 66 (31.6) | 39 (33.9) | 27 (28.7) | |
| Social vulnerability index, n (%) | ||||
| Q1 (least vulnerable) | 50 (23.8) | 25 (21.6) | 25 (26.6) | 0.26 |
| Q2 | 62 (29.5) | 40 (34.5) | 22 (23.4) | |
| Q3 | 57 (27.1) | 32 (27.6) | 25 (26.6) | |
| Q4 (most vulnerable) | 41 (19.5) | 19 (16.4) | 22 (23.4) | |
| Asthma, n (%) | ||||
| Yes | 89 (42.4) | 55 (47.4) | 34 (36.2) | 0.1 |
| No | 121 (57.6) | 61 (52.6) | 60 (63.8) | |
| Allergic rhinitis, n (%) | ||||
| Yes | 115 (54.8) | 64 (55.2) | 51 (54.3) | 0.89 |
| No | 95 (45.2) | 52 (44.8) | 43 (45.7) | |
| IgE (count), n (range)d | 258 (55–803) | 277 (53–997) | 216.5 (66–779) | 0.6 |
| Eosinophil (count), n (range)e | 396 (152–975) | 398 (143.5–879.5) | 360 (216–1302) | 0.66 |
| Eosinophil (%), n (range)f | 4 (2–8) | 4 (2–8) | 4 (2–7) | 0.73 |
| Smoking, n (%) | ||||
| Current smoker | 8 (3.8) | 4 (3.5) | 4 (4.3) | 1.00 |
| Nonsmoker | 159 (75.7) | 88 (75.9) | 71 (75.5) | |
| Former smoker | 43 (20.5) | 24 (20.7) | 19 (20.2) | |
Disease severity defined by the presence of ≥ 1 major criteria (CT scan with bony erosion; CT scan with orbitocranial extension), or ≥ 2 minor criteria (Lund–Mackay score of 12 for unilateral disease; Lund–Mackay score of 24 for bilateral disease; ≥ 2 sinus surgical procedures; ≥ 3 courses of oral corticosteroids).
p Value calculated using the Student’s t-test.
p Value calculated using the Mann-Whitney test.
113 patients missing IgE values.
187 patients missing eosinophil count.
13 patients missing eosinophil count.
AFRS, allergic fungal rhinosinusitis; CT, computed tomography; IgE, immunoglobulin E; NDI, neighborhood deprivation index; Q, quartile; SD, standard deviation.