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. 2024 Jul 9;19(7):e0307052. doi: 10.1371/journal.pone.0307052

Fig 5. iMDK inhibited the PI3K/AKT pathway and influenced the apoptosis pathway.

Fig 5

A. Dose-dependently, phosphorylation of PI3K and AKT and the expression of survivin and XIAP, anti-apoptotic factors, were decreased while the expression of BAD, a pro-apoptotic factor, was increased 48 hours after treatment with iMDK. Shown is immunoblot performed as described in Methods. B. Time-dependently, phosphorylation of PI3K and AKT and the expression of survivin and XIAP were decreased while the expression of BAD was increased by treatment with iMDK at a concentration of 50 nM. Immunoblot was performed as described in Methods.