Table 1.
Demographic characteristics of patients with urothelial carcinoma with oncogenic FGFR3 alterations.
| Characteristic, no. (%) or median (range) | Patients with oncogenic FGFR3 alterations (n = 390) | Patients with oncogenic FGFR3 mutations (n = 354) | Patients with oncogenic FGFR3 fusions (n = 36) | Patients without oncogenic FGFR3 alterations (n = 1031) | With versus without FGFR3 oncogenic alterations | FGFR3 oncogenic mutation versus no oncogenic FGFR3 alteration | FGFR3 oncogenic fusions versus FGFR3 oncogenic mutations |
|---|---|---|---|---|---|---|---|
| Age | 67.8 (18.3–90.3) | 68.4 (29.6–89.5) | 61.8 (18.3–90.3) | 68.4 (32.2–99.6) | p = .030a | ||
| Male gender | 264 (67.5) | 239 (67.3) | 25 (69.4) | 798 (77.4) | p = .0002b | p = .0003b | |
| Race/Ethnicity | |||||||
| Caucasian, Non-Hispanic | 333 (90.0) | 304 (90.5) | 29 (85.3) | 820 (87.3) | |||
| Hispanic | 13 (3.5) | 10 (3.0) | 3 (8.8) | 36 (3.8) | |||
| African American | 12 (3.2) | 12 (3.6) | 0 (0) | 34 (3.6) | |||
| Asian | 11 (3.0) | 9 (2.7) | 2 (5.9) | 42 (4.5) | |||
| Native American | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (0.1) | |||
| Other | 1 (0.3) | 1 (0.3) | 0 (0.0) | 6 (0.6) | |||
| Unknown | 20 | 18 | 2 | 92 | |||
| Smoking history | 256 (67.0) | 240 (69.4) | 16 (44.4) | 627 (63.4) | p = .005b |
a
Wilcoxon rank-sum test
b
Fisher’s exact test