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. Author manuscript; available in PMC: 2024 Jul 9.
Published in final edited form as: Regen Eng Transl Med. 2023 Jul 28;10(2):147–171. doi: 10.1007/s40883-023-00313-1

Table 3.

Summary of outcomes of knee sleeve used in clinical and documented experimental studies

Author, year Sample Sample size Study design Age, mean SD (years) Study duration Outcome measures Results
Mohd Sharif et al., 2019 [92] Simple knee sleeve vs knee sleeve with patella cutout Female (15), Male (2) Comparative study 47.7 ± 9.7 6 weeks WOMAC Significant reduction in pain, early stance, and late stance knee adduction moment
Schween et al., 2015 [100] Knee Sleeve
Osteoarthritis of the medial tibiofemoral joint
Male (19)
Female (8)
A prospective comparative study (with/without elastic knee sleeve) 50 ± 9 Immediate Kinetic gait analysis Knee adduction angle at ground contact was reduced by 1.9 ± 2.1° with the use of a sleeve
Peak knee adduction was reduced by 1.5 ± 6°
Kwon et al., 2014 [95] Knee sleeve
Patients with a history of ACL reconstruction
Male (13) Randomized controlled trial (pre/post-silicon sleeve application) 28.27 Immediate Dynamic balance tests, TUG, stair step test,
vertical jump test,
proprioception test,
isokinetic knee strength test
Application of silicone sleeve showed significant effects in proprioceptive function on the operated side compared to both taping and control conditions
Muscle strength on the operated side of the quadriceps and hamstring was significantly improved compared with none or taping
Giotis et al., 2013 [99] Knee sleeve
Patients with a history of unilateral ACL reconstruction with BPTB autograft
Male (20) A prospective comparative study (prophylactic brace/patellofemoral brace (sleeve)/non-braced) 27.1 ± 3.4 Immediate Kinematic data The range of motion of tibial rotation was significantly lower in the intact knee compared with all 3 conditions of the ACL-reconstructed knee
Placing a brace or a sleeve on the ACL-reconstructed knee resulted in lower rotation than in the non-braced condition
Collins et al, 2012 [93] Knee sleeve
Knee OA
Male (22)
Female (30)
Counterbalanced, repeated measures with SRES 61.2 ±9.6 Immediate Center of pressure displacement Neoprene knee sleeves show no significant improvement in knee balance
Mortaza et al, 2012 [119] Knee sleeve and prophylactic knee brace
Healthy male collegiate athletes
Male (31) Cross-over randomized controlled trial
Prophylactic knee brace with neoprene knee sleeves
21.2 ± 1.5 Immediate Single-leg vertical jump test
Cross-over hop tst.
Isokinetic Strength Test
No statistical significance was found between the 4 (non-braced control, a neoprene sleeve, a neoprene sleeve with four metal supports, and prophylactic knee brace) testing conditions while performing the single-leg vertical jump test and the cross-over hop tests
Collins et al., 2011 [93] knee sleeve
Stochastic resonance ES+knee sleeve
Knee OA
Male (22)
Female (30)
Counterbalance sequence design of two treatment conditions (stochastic resonance ES+knee sleeve/knee sleeve/no sleeve+ES) 61.2 (9.6) Immediate Kinetic gait data
Kinematic gait data
EMG data
75% threshold/sleeve and sleeve-only conditions resulted in increased knee flexion at contact and reduced loading rates compared to the control condition
Muscle co-contraction was found to decrease with the 75% threshold/sleeve condition compared to the other conditions
Bryk et al., 2011 [58] Knee sleeve Knee OA 74 Randomized controlled trial (with or without knee sleeves) SCPT, TUG test, 8MW test, VAS for pain Statistically significant reduction in pain with knee sleeve use compared to without knee sleeve use
Statistically significant improvements in 8MW and TUG tests sleeve use compared to without knee sleeve use
Wilson et al., 2010 [97] Knee sleeve
Cadaver lower extremities
Male (4)
Female (5)
Cross-over study (knee sleeve, patellar stabilization sleeve, patellar stabilization brace, control) 62.7 (52–75) Immediate Contact area & pressure All braces increased contact area, but the wrap-style patellar stabilization brace decreased peak pressure on the PF joint
A decrease in magnitude and proximal shift in the location of the peak PF pressure was demonstrated with a wrap-style patellar stabilization brace
Both patellar stabilization sleeves and the knee sleeve significantly increased contact area compared with the wrap-style patellar stabilization brace
Birmingham et al., 2008 [120] Functional knee brace compared to knee sleeve Brace:
Male (36)
Female (40)
Sleeve:
Male (37)
Female (37)
Randomized controlled clinical trial (functional knee brace/neoprene sleeve) Brace: 26.8 ± 8.9
Sleeve: 28.2 ± 10.1
2 years ACL-Quality of Life Questionnaire
Anterior tibial translation single limb forward hop test.
Tegner Activity Scale
Subjective questionnaire
No significant difference between brace and sleeve drops for any outcomes at 1- and 2-year follow-ups
Subjective ratings of confidence in the knee provided by the brace/sleeve were higher for the brace group than the sleeve group
Van Tiggelen et al.,
2008 [l02]
Knee sleeve
Healthy subjects
Male (49)
Female (15)
A prospective comparative study (with/without elastic knee sleeve) 24.44 ± 4.56 Immediate Proprioception On the braced side, no significant differences were observed between the baseline assessment and the third assessment
Neoprene knee sleeves compensate for the deficit in joint position sense due to fatigue
Chuang et al., 2007 [89] Knee sleeve
Knee OA
Male (8)
Female (42)
Cross-over randomized controlled trial (with or without neoprene sleeve) 61.24 ± 8.8 (group A)
64.32 ± 10.4 (group B)
Immediate Static & dynamic balance tests Knee OA subjects wearing knee sleeves showed better balance control in static and dynamic conditions than those without neoprene sleeves
Miller et al., 2005 [98] Knee sleeve
D1 collegiate athletes
Male (12)
Female (12)
A 2 × 2 × 3 × 5 factorial design with replicated measures on 3 variables 21.79 Immediate Skin (an anterior aspect of thigh) and muscle (vests lateralis) temperature Thigh sleeve showed no effect on intramuscular temperature before or during exercise, but post-exercise temperatures averaged 0.5 °C higher
Exercise intensity showed 1.3 to 2.0 °C increases in temperature with sleeve use
Females showed higher intramuscular temperatures than males when donning sleeves; however, males had higher skin temperatures than females
Mazzuca et al., 2004 [88] Knee sleeve
Knee OA
Male (12)
Female (40)
Double-blind, randomized controlled trial (verum sleeve/placebo sleeve) 62.7 ± 11.2 8 weeks
Don sleeves for 12 h daily for 4 weeks
WOMAC Subjects with verum sleeves reported a decrease in mean WOMAC pain score relative to baseline
No statistically significant difference between groups
Hassan et al., 2002 [86] Knee bandage
Knee OA
Male (19)
Female (49)
Cross-over, within-subject study (randomized, standard-sized/loose-sized bandages, pre- and post-time points) 67.1 (36–87) 2 weeks/treatment arm VAS
WOMAC
Static postural sway
Proprioceptive acuity
The standard-sized bandage did not affect knee pain, proprioception, or postural sway
Proprioceptive acuity and postural sway improved with looser bandages, but the benefit was lost upon removal
Kirkley et al., 1999 [38] Knee sleeve
Patients with varus gonarthrosis+knee OA
Male (86)
Female (33)
Prospective, parallel group, randomized clinical trial (unloader knee brace/neoprene sleeve/control) 59.5 6 months WOMAC
MACTAR
Assess function:
6-MWT, 30-second stair-climbing test
Improvement in disease-specific quality of life and function in both knee brace groups compared with the control group
A significant difference between the unloader brace group and the neoprene-sleeve group in pain after 6-MWT and 30-s stair-climbing test
Te unloader brace was, on average, more effective than the neoprene sleeve
McNair et al., 1996 [15] Knee sleeve
Healthy subjects
Male (10)
Female (10)
2 × 2 Latin square cross-over design (with/without knee sleeve) 28 (5) Immediate Angle and force data 11 % improvement in tracking when subjects wore the knee brace