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. 2024 Jul 9;12(13):e16134. doi: 10.14814/phy2.16134

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© 2024 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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IL‐6 and sICAM‐1 concentrations were significantly increased in Sepsis+ARDS patient plasma (n = 10) compared with healthy plasma (n = 5) following incubation in the endothelial cell (EC) lumens (1584.2 pg/mL, IQR 1892.0 vs. 621.8 pg/mL, IQR 258.1, p = 0.03 and 100118.5 pg/mL, IQR 159832.3 vs. −19934.6 pg/mL, IQR 61657.0, p = 0.04 for IL‐6 and sICAM‐1 respectively). IL‐6 and sICAM‐1 concentrations were numerically higher in Sepsis + ARDS plasma than Sepsis without ARDS plasma (n = 10) following incubation in the EC lumens but did not reach statistical significance. Table S1 summarizes cytokine concentrations.