Table 3.
White blood cell count and lymphocytes changes over the follow-up in patients treated with siponimod
| Month 0 | Month 3 | Coeff. | 95% CI | Month 6 | Coeff. | 95% CI | Month 12 | Coeff. | 95% CI | Month 24 | Coeff. | 95% CI | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number of patients | 46 | 19 | 27 | 32 | 14 | ||||||||||||
| Lymphocytes, mean ± SD | 1029 ± 689 | 558 ± 372 | −482.19 | −696.34 | −268.05 | 417 ± 225 | −566.57 | −754.63 | −378.51 | 359.98 ± 153.64 | −653.90 | −831.59 | −476.22 | 300 ± 83 | −705.66 | −946.35 | −464.97 |
| T lymphocyte, mean ± SD | 57.35 ± 18.06 | 48.74 ± 13.68 | −8.86 | −16.17 | −1.56 | 38.48 ± 16.25 | −17.25 | −23.63 | −10.87 | 38.34 ± 18 | −18.67 | −24.68 | −12.66 | 35.93 ± 14.5 | −21.18 | −29.43 | −12.94 |
| B lymphocytes, mean ± SD | 9.85 ± 6.76 | 4.76 ± 3.15 | −3.77 | −6.02 | −1.53 | 7.3 ± 5.5 | −2.56 | −4.52 | −0.60 | 7 ± 5.61 | −2.513 | −4.35 | −0.67 | 7.43 ± 6.44 | −2.89 | −5.44 | −0.35 |
| CD4+ lymphocytes, mean ± SD | 36.72 ± 16.38 | 19.37 ± 11.77 | −16.87 | −23.31 | −10.43 | 18.52 ± 10.34 | −18.10 | −23.95 | −12.41 | 15 ± 9.36 | −21.65 | −27.05 | −16.26 | 12.64 ± 7.08 | −24.36 | −31.57 | −17.15 |
| CD8+ lymphocytes, mean ± SD | 16.91 ± 6.73 | 23.53 ± 9.57 | 5.47 | 1.91 | 9.03 | 15.74 ± 8.51 | −0.25 | −3.35 | 2.85 | 16.94 ± 11.07 | −0.32 | −3.25 | 2.59 | 18 ± 11.22 | 1.02 | −3.00 | 5.05 |
| CD4/CD8 ratio, mean ± SD | 2.46 ± 1.49 | 1.08 ± 1.3 | −1.02 | −1.60 | −0.44 | 1.75 ± 1.71 | −0.68 | −1.17 | −0.18 | 1.24 ± 1.23 | −1.11 | −1.61 | −0.61 | 1.21 ± 1.82 | −4.36 | −6.55 | −2.17 |
| NK lymphocytes, mean ± SD | 14.61 ± 11.31 | 29.47 ± 17.25 | 13.92 | 6.84 | 21.00 | 28.69 ± 14.19 | 13.75 | 7.48 | 20.02 | 34.22 ± 19.62 | 19.35 | 13.51 | 25.18 | 33.36 ± 20.16 | 18.47 | 10.49 | 26.45 |
| CD3+CD20+ lymphocytes, mean ± SD | 0.32 ± 0.63 | 0.12 ± 0.24 | −0.19 | −0.43 | 0.06 | 0.11 ± 0.41 | −0.20 | −0.42 | 0.02 | 0.08 ± 0.44 | −0.24 | −0.45 | −0.03 | 0 ± 0 | −0.32 | −0.59 | −0.04 |
| Naïve regulatory T cells, mean ± SD | 0.18 ± 0.31 | 0.08 ± 0.15 | −0.1 | −0.20 | 0.002 | 0.07 ± 0.1 | −0.12 | −0.21 | −0.02 | 0.03 ± 0.07 | −0.16 | −0.24 | −0.07 | 0.03 ± 0.06 | −0.15 | −0.27 | −0.04 |
| Memory regulatory T cells, mean ± SD | 0.7 ± 0.45 | 0.59 ± 0.58 | −0.11 | −0.43 | 0.20 | 1.01 ± 0.81 | 0.30 | 0.02 | 0.58 | 0.79 ± 0.71 | 0.09 | −0.18 | 0.36 | 0.54 ± 0.35 | −0.16 | −0.51 | 0.19 |
| Naïve regulatory B cells, mean ± SD | 0.52 ± 0.71 | 0.63 ± 0.49 | 0.28 | −0.33 | 0.90 | 1.33 ± 1.16 | 0.84 | 0.30 | 1.38 | 1.53 ± 1.7 | 1.03 | 0.51 | 1.54 | 1.98 ± 2.32 | 1.49 | 0.80 | 2.18 |
| Memory regulatory B cells, mean ± SD | 1.17 ± 1.54 | 0.41 ± 0.62 | −0.57 | −0.97 | −0.17 | 0.49 ± 0.65 | −0.63 | −1.00 | −0.28 | 0.47 ± 0.8 | −0.61 | −0.94 | −0.28 | 0.41 ± 0.53 | −0.78 | −1.24 | −0.33 |
Coefficients and 95% CI were obtained through age-, sex-, genotype and DMT category-corrected generalized linear mixed-effect regression models using baseline values as reference
CI confidence interval, NK natural killer, SD standard deviation