Fig. 1.

HOTAIR, a LncRNA, is increased in EC tissues and cell lines (A) RT-qPCR revealed that LncRNA HOTAIR expression was considerably greater in EC tissues (n = 58) than in neighbouring tissues (n = 58). (B) Kaplan-Meier survival curve analysis shows that EC tissues expressing high levels of HOTAIR had a considerably higher 5-year survival rate than neighbouring tissues expressing low levels of HOTAIR. (C) RT-qPCR study of HOTAIR expression levels in HEC-1 A, HEC-1B, RL95-2, and KLE cell lines. (D) HOTAIR knockdown drastically reduced HEC-1 A and KLE cell viability. Data from at least three replicates were presented as mean ± standard deviation (SD). *P < 0.05, **P < 0.01