Fig. 6.

Overexpression of SOX17 Significantly Weakens the Inhibitory Effect of oe-ZBTB7A on Malignant Biological Behaviors in Endometrial Cancer Cells. After further overexpression of SOX17 in HEC-1 A and KLE cell lines with overexpressed ZBTB7A (A) There was a significant increase in the levels of SOX17. (B) Plate cloning experiments indicated a partial recovery in cell proliferation capability. (C) Transwell assays demonstrated a restoration in cell invasion and migration capabilities following SOX17 overexpression. (D) Western Blot analysis revealed significant increases in the protein expression levels of CD31 and VEGFA. (E) Tube formation assays showed an increase in the number of blood vessels formed. Data from at least three replicates were presented as mean ± standard deviation (SD). *P < 0.05, **P < 0.01